Evaluation of the Effect of Hydroethanol Extract of Osmundastrum Cinnamomeum on the Liver function of Castor Oil-Induced Diarrhea in Wistar Rats
Keywords:
osmundastrum cinnamomeum, aspartate aminotransferase, alanine aminotransferase, castor oil, diarrhea., wistar ratsAbstract
The present study was carried out to evaluate the liver function effect of hydroethanol leaf extract of Osmundastrum cinnamomeum on castor oil –induced diarrhea in wistar rats. Thirty five wistar albino rats were divided into seven groups with five rats in each group. Rats in group A served as the normal control and was given water throughout the experiment, group B served as the negative control and was given only 0.5ml of castor oil by oral gavage, group C served as the positive control and was given 0.5ml of castor oil and 5mg/kg loperamide (standard drug), group D received 100mg/kg of extract before 0.5ml of castor oil (pre-treatment), group E received 300mg/kg of extract before 0.5ml of castor oil (pre-treatment), group F received 0.5ml of castor oil and 100mg/kg of extract (Post-treatment), group G received 0.5ml of castor oil and 300mg/kg of extract (Post-treatment). The biomarker enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), direct bilirubin (DB) and total bilirubin (TB) were investigated and their values for the above groups showed that there was no significant (P>0.05) difference on the values of the enzymes when compared with the standard range of accepted values for liver function tests which are: ALT (10-55/L), AST (10-40/L), ALP (45-115/L), DB (less than 5.1-20.5mol/L). The study demonstrated that Osmundastrum cinnamomeum did not have any negative significant effect on the liver function and may be used in the management of liver diseases.
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